Mechanisms and Consequences of Antigen Presentation by CD1.

Inhibition of CD1 antigen presentation by human cytomegalovirus.

The betaherpesvirus human cytomegalovirus (HCMV) encodes several molecules that block antigen presentation by the major histocompatibility complex (MHC) proteins. Humans also possess one other family of antigen-presenting molecules, the CD1 family; however, the effect of HCMV on CD1 expression is unknown. The majority of CD1 molecules are classified on the basis of homology as group 1 CD1 and a...

Glycolipid Presentation by CD1

T cells recognize lipid antigens as complexes associated with CD1 antigen-presenting molecules. The biophysical properties of lipids impose unique mechanisms for lipid delivery, cell internalization, membrane trafficking, processing of large glycolipid antigens and loadingofCD1molecules. T cells specific for lipid antigens participate in the regulation of immune response, protection during infe...

Glycolipid targets of CD1-mediated T-cell responses.

Members of the CD1 family of antigen-presenting molecules bind and present a variety of mammalian and microbial glycolipids for specific recognition by T cells. CD1 proteins accomplish their antigen-presenting function by binding the alkyl chains of the antigens within a deep, hydrophobic groove on the membrane distal surface of CD1, making the hydrophilic elements of the antigen available for ...

Simplex Virus Immune Evasion Dendritic Cells as a Target for Herpes CD1 Antigen Presentation by Human

Chaperoning antigen presentation by MHC class II molecules and their role in oncogenesis.

Tumor vaccine development aimed at stimulating the cellular immune response focuses mainly on MHC class I molecules. This is not surprising since most tumors do not express MHC class II or CD1 molecules. Nevertheless, the most successful targets for cancer immunotherapy, leukemia and melanoma, often do express MHC class II molecules, which leaves no obvious reason to ignore MHC class II molecul...